MovDisordV3, Main, Exploration, bibRecord, 000747

The VPS35 gene and Parkinson's disease.

Identifieur interne : 000747 ( Main/Exploration ); précédent : 000746; suivant : 000748

The VPS35 gene and Parkinson's disease.

Auteurs : Hao Deng [République populaire de Chine] ; Kai Gao ; Joseph Jankovic [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:23536430

English descriptors

KwdEn :
- Animals, Female, Genetic Predisposition to Disease, Humans, Male, Mutation (genetics), Parkinson Disease (genetics), Transcription Factors (genetics), Vesicular Transport Proteins (genetics).
MESH :
- chemical , genetics : Transcription Factors, Vesicular Transport Proteins.
- genetics : Mutation, Parkinson Disease.
- Animals, Female, Genetic Predisposition to Disease, Humans, Male.

Abstract

Parkinson's disease (PD), the second most common age-related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder.

DOI: 10.1002/mds.25430
PubMed: 23536430

Affiliations:

Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China. hdeng008@yahoo.com</nlm:affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD), the second most common age-related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder.</div>
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<country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
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Movement Disorders (revue)

The VPS35 gene and Parkinson's disease.

The VPS35 gene and Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.